Targets → AR

AR

Androgen receptor

P10275 ↗
7 Targeting Drugs
22 Resistance Mutations
8E1A Structure Loaded
3D Structure PDB: 8E1A
Switch structure: RCSB ↗
Protein Information
UniProt Accession P10275 ↗
Gene Name AR
Cellular Location Nucleus
General Function Zinc ion binding
Targeting Drugs 7
Bicalutamide Androgen Receptor Antagonist
confirmed →
Enzalutamide Androgen Receptor Antagonist
confirmed →
Flutamide Androgen Receptor Antagonist
confirmed →
Nilutamide Androgen Receptor Antagonist
confirmed →
Diethylstilbestrol Hormone Therapy
→
Mitotane
→
Tamoxifen Hormone Therapy
→
Resistance Mutations Across All Drugs
Mutation Drug Source Resistance Samples
p.T878A Flutamide COSMIC 28
p.T346A Flutamide COSMIC 28
p.H733R Flutamide COSMIC 28
p.T695A Flutamide COSMIC 28
p.Q641* Flutamide COSMIC 28
p.Q109* Flutamide COSMIC 28
p.Q451* Flutamide COSMIC 28
p.T878S Flutamide COSMIC 28
p.T346S Flutamide COSMIC 28
p.H733Q Flutamide COSMIC 28
p.T695S Flutamide COSMIC 28
p.V716M Flutamide COSMIC 28
p.V184M Flutamide COSMIC 28
p.V526M Flutamide COSMIC 28
p.T878A Enzalutamide COSMIC 8
p.F877L Enzalutamide COSMIC 8
p.T346A Enzalutamide COSMIC 8
p.F345L Enzalutamide COSMIC 8
p.H733R Enzalutamide COSMIC 8
p.V732A Enzalutamide COSMIC 8
p.T695A Enzalutamide COSMIC 8
p.F694L Enzalutamide COSMIC 8