ALK
ALK tyrosine kinase receptor
2
Targeting Drugs
49
Resistance Mutations
7MZY
Structure Loaded
Protein Information
UniProt Accession
Q9UM73 ↗
Gene Name
ALK
Cellular Location
Cell membrane
General Function
Transmembrane receptor protein tyrosine kinase activity
Targeting Drugs
2
Resistance Mutations Across All Drugs
| Mutation | Drug | Source | Resistance Samples |
|---|---|---|---|
| p.S1206Y | Crizotinib | COSMIC | 158 |
| p.S829Y | Crizotinib | COSMIC | 158 |
| p.S138Y | Crizotinib | COSMIC | 158 |
| p.G1202R | Crizotinib | COSMIC | 158 |
| p.G825R | Crizotinib | COSMIC | 158 |
| p.G134R | Crizotinib | COSMIC | 158 |
| p.L1196M | Crizotinib | COSMIC | 158 |
| p.L819M | Crizotinib | COSMIC | 158 |
| p.L128M | Crizotinib | COSMIC | 158 |
| p.T1151dup | Crizotinib | COSMIC | 158 |
| p.T774dup | Crizotinib | COSMIC | 158 |
| p.T83dup | Crizotinib | COSMIC | 158 |
| p.F1174L | Crizotinib | COSMIC | 158 |
| p.F797L | Crizotinib | COSMIC | 158 |
| p.F106L | Crizotinib | COSMIC | 158 |
| p.G1269A | Crizotinib | COSMIC | 158 |
| p.G892A | Crizotinib | COSMIC | 158 |
| p.G201A | Crizotinib | COSMIC | 158 |
| p.C1156Y | Crizotinib | COSMIC | 158 |
| p.C779Y | Crizotinib | COSMIC | 158 |
| p.C88Y | Crizotinib | COSMIC | 158 |
| p.F1174V | Crizotinib | COSMIC | 158 |
| p.F797V | Crizotinib | COSMIC | 158 |
| p.F106V | Crizotinib | COSMIC | 158 |
| p.I1171T | Crizotinib | COSMIC | 158 |
| p.I794T | Crizotinib | COSMIC | 158 |
| p.I103T | Crizotinib | COSMIC | 158 |
| p.G1128A | Crizotinib | COSMIC | 158 |
| p.G751A | Crizotinib | COSMIC | 158 |
| p.G60A | Crizotinib | COSMIC | 158 |
| p.T1151M | Crizotinib | COSMIC | 158 |
| p.T1151R | Crizotinib | COSMIC | 158 |
| p.L1152R | Crizotinib | COSMIC | 158 |
| p.C1156F | Crizotinib | COSMIC | 158 |
| p.F1174C | Crizotinib | COSMIC | 158 |
| p.S1206F | Crizotinib | COSMIC | 158 |
| p.E1210K | Crizotinib | COSMIC | 158 |
| p.G1202R | Ceritinib | COSMIC | 25 |
| p.F1174C | Ceritinib | COSMIC | 25 |
| p.F1174V | Ceritinib | COSMIC | 25 |
| p.G1123S | Ceritinib | COSMIC | 25 |
| p.G746S | Ceritinib | COSMIC | 25 |
| p.G55S | Ceritinib | COSMIC | 25 |
| p.D1203N | Ceritinib | COSMIC | 25 |
| p.D826N | Ceritinib | COSMIC | 25 |
| p.D135N | Ceritinib | COSMIC | 25 |
| p.L1196M | Ceritinib | COSMIC | 25 |
| p.G1202del | Ceritinib | COSMIC | 25 |
| p.F1174L | Ceritinib | COSMIC | 25 |