SMO
Smoothened homolog
2
Targeting Drugs
10
Resistance Mutations
4JKV
Structure Loaded
Protein Information
UniProt Accession
Q99835 ↗
Gene Name
SMO
Cellular Location
Membrane
General Function
Wnt-protein binding
Targeting Drugs
2
Resistance Mutations Across All Drugs
| Mutation | Drug | Source | Resistance Samples |
|---|---|---|---|
| p.D473H | Vismodegib | COSMIC | 16 |
| p.D473Y | Vismodegib | COSMIC | 16 |
| p.W281L | Vismodegib | COSMIC | 16 |
| p.V321M | Vismodegib | COSMIC | 16 |
| p.A459V | Vismodegib | COSMIC | 16 |
| p.C469Y | Vismodegib | COSMIC | 16 |
| p.T241M | Vismodegib | COSMIC | 16 |
| p.D473G | Vismodegib | COSMIC | 16 |
| p.Q477E | Vismodegib | COSMIC | 16 |
| p.S533N | Vismodegib | COSMIC | 16 |