BTK
Tyrosine-protein kinase BTK
2
Targeting Drugs
11
Resistance Mutations
5P9J
Structure Loaded
Protein Information
UniProt Accession
Q06187 ↗
Gene Name
BTK
Cellular Location
Cytoplasm
General Function
Protein tyrosine kinase activity
Targeting Drugs
2
Resistance Mutations Across All Drugs
| Mutation | Drug | Source | Resistance Samples |
|---|---|---|---|
| p.C481S | Ibrutinib | COSMIC | 256 |
| p.C481R | Ibrutinib | COSMIC | 256 |
| p.C481Y | Ibrutinib | COSMIC | 256 |
| p.? | Ibrutinib | COSMIC | 256 |
| p.C515S | Ibrutinib | COSMIC | 256 |
| p.C515R | Ibrutinib | COSMIC | 256 |
| p.C515Y | Ibrutinib | COSMIC | 256 |
| p.C481F | Ibrutinib | COSMIC | 256 |
| p.C515F | Ibrutinib | COSMIC | 256 |
| p.T316A | Ibrutinib | COSMIC | 256 |
| p.T350A | Ibrutinib | COSMIC | 256 |