MTOR

Serine/threonine-protein kinase mTOR

2 Targeting Drugs

2 Resistance Mutations

4DRI Structure Loaded

3D Structure PDB: 4DRI

Switch structure: RCSB ↗

Protein Information

UniProt Accession P42345 ↗

Gene Name MTOR

Cellular Location Endoplasmic reticulum membrane

General Function Tfiiic-class transcription factor binding

Targeting Drugs 2

Resistance Mutations Across All Drugs

Mutation	Drug	Source	Resistance Samples
p.F2108L	Everolimus	COSMIC	2
p.F313L	Everolimus	COSMIC	2