CDKN1A
Cyclin-dependent kinase inhibitor 1
1
Targeting Drugs
0
Resistance Mutations
2ZVV
Structure Loaded
Protein Information
UniProt Accession
P38936 ↗
Gene Name
CDKN1A
Cellular Location
Cytoplasm
General Function
May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).
Targeting Drugs
1