PDGFRA

Platelet-derived growth factor receptor alpha

5 Targeting Drugs
3 Resistance Mutations
5GRN Structure Loaded
3D Structure PDB: 5GRN
Switch structure: RCSB ↗
Protein Information
UniProt Accession P16234 ↗
Gene Name PDGFRA
Cellular Location Cell membrane
General Function Vascular endothelial growth factor-activated receptor activity
Resistance Mutations Across All Drugs
Mutation Drug Source Resistance Samples
p.D842V Imatinib COSMIC 866
p.H687Y Imatinib COSMIC 866
p.D842V Sunitinib COSMIC 9