BRAF

Serine/threonine-protein kinase B-raf

4 Targeting Drugs

5 Resistance Mutations

8VSO Structure Loaded

3D Structure PDB: 8VSO

Switch structure: RCSB ↗

Protein Information

UniProt Accession P15056 ↗

Gene Name BRAF

Cellular Location Nucleus

General Function Protein serine/threonine kinase activity

Targeting Drugs 4

Resistance Mutations Across All Drugs

Mutation	Drug	Source	Resistance Samples
p.?	Vemurafenib	COSMIC	96
p.L545H	Vemurafenib	COSMIC	96
p.L505H	Vemurafenib	COSMIC	96
p.V47_D380del	Vemurafenib	COSMIC	96
p.?	Dabrafenib	COSMIC	64