KIT
Mast/stem cell growth factor receptor Kit
9
Targeting Drugs
28
Resistance Mutations
2VIF
Structure Loaded
Protein Information
UniProt Accession
P10721 ↗
Gene Name
KIT
Cellular Location
Cell membrane
General Function
Transmembrane receptor protein tyrosine kinase activity
Targeting Drugs
9
Resistance Mutations Across All Drugs
| Mutation | Drug | Source | Resistance Samples |
|---|---|---|---|
| p.D816H | Imatinib | COSMIC | 866 |
| p.Y823D | Imatinib | COSMIC | 866 |
| p.N822K | Imatinib | COSMIC | 866 |
| p.V654A | Imatinib | COSMIC | 866 |
| p.C809G | Imatinib | COSMIC | 866 |
| p.S709F | Imatinib | COSMIC | 866 |
| p.D820G | Imatinib | COSMIC | 866 |
| p.D816E | Imatinib | COSMIC | 866 |
| p.D820E | Imatinib | COSMIC | 866 |
| p.D820Y | Imatinib | COSMIC | 866 |
| p.T670I | Imatinib | COSMIC | 866 |
| p.T670E | Imatinib | COSMIC | 866 |
| p.K642E | Imatinib | COSMIC | 866 |
| p.(P627_G664)Xfs*? | Imatinib | COSMIC | 866 |
| p.A829P | Imatinib | COSMIC | 866 |
| p.D820A | Imatinib | COSMIC | 866 |
| p.D816A | Imatinib | COSMIC | 866 |
| p.N822Y | Imatinib | COSMIC | 866 |
| p.D579del | Imatinib | COSMIC | 866 |
| p.Y578C | Imatinib | COSMIC | 866 |
| p.N680K | Imatinib | COSMIC | 866 |
| p.K818_D820>N | Imatinib | COSMIC | 866 |
| p.V569_Y578del | Imatinib | COSMIC | 866 |
| p.S821F | Imatinib | COSMIC | 866 |
| p.D716N | Imatinib | COSMIC | 866 |
| p.D816G | Imatinib | COSMIC | 866 |
| p.D820V | Imatinib | COSMIC | 866 |
| p.N655T | Nilotinib | COSMIC | 3 |