MET
Hepatocyte growth factor receptor
2
Targeting Drugs
10
Resistance Mutations
9T6K
Structure Loaded
Protein Information
UniProt Accession
P08581 ↗
Gene Name
MET
Cellular Location
Membrane
General Function
Protein tyrosine kinase activity
Targeting Drugs
2
Resistance Mutations Across All Drugs
| Mutation | Drug | Source | Resistance Samples |
|---|---|---|---|
| p.D1246N | Crizotinib | COSMIC | 158 |
| p.D1228N | Crizotinib | COSMIC | 158 |
| p.Y1248C | Crizotinib | COSMIC | 158 |
| p.Y1230C | Crizotinib | COSMIC | 158 |
| p.Y1248H | Crizotinib | COSMIC | 158 |
| p.D1246H | Crizotinib | COSMIC | 158 |
| p.Y1248S | Crizotinib | COSMIC | 158 |
| p.G1181R | Crizotinib | COSMIC | 158 |
| p.Y1230H | Crizotinib | COSMIC | 158 |
| p.D1249Y | Crizotinib | COSMIC | 158 |