ERBB2
Receptor tyrosine-protein kinase erbB-2
5
Targeting Drugs
4
Resistance Mutations
8VB5
Structure Loaded
Protein Information
UniProt Accession
P04626 ↗
Gene Name
ERBB2
Cellular Location
Cell membrane
General Function
Transmembrane signaling receptor activity
Resistance Mutations Across All Drugs
| Mutation | Drug | Source | Resistance Samples |
|---|---|---|---|
| p.L869R | Trastuzumab | COSMIC | 18 |
| p.L839R | Trastuzumab | COSMIC | 18 |
| p.L593R | Trastuzumab | COSMIC | 18 |
| p.L854R | Trastuzumab | COSMIC | 18 |