EGFR
Epidermal growth factor receptor
8
Targeting Drugs
12
Resistance Mutations
8A27
Structure Loaded
Protein Information
UniProt Accession
P00533 ↗
Gene Name
EGFR
Cellular Location
Cell membrane
General Function
Ubiquitin protein ligase binding
Resistance Mutations Across All Drugs
| Mutation | Drug | Source | Resistance Samples |
|---|---|---|---|
| p.T790M | Gefitinib | COSMIC | 394 |
| p.T745M | Gefitinib | COSMIC | 394 |
| p.? | Gefitinib | COSMIC | 394 |
| p.D761Y | Gefitinib | COSMIC | 394 |
| p.D716Y | Gefitinib | COSMIC | 394 |
| p.T790M | Erlotinib | COSMIC | 122 |
| p.T745M | Erlotinib | COSMIC | 122 |
| p.? | Erlotinib | COSMIC | 122 |
| p.T790M | Afatinib | COSMIC | 73 |
| p.T745M | Afatinib | COSMIC | 73 |
| p.? | Afatinib | COSMIC | 73 |
| p.C797S | Afatinib | COSMIC | 73 |