ABL1
Tyrosine-protein kinase ABL1
6
Targeting Drugs
63
Resistance Mutations
5OAZ
Structure Loaded
Protein Information
UniProt Accession
P00519 ↗
Gene Name
ABL1
Cellular Location
Cytoplasm
General Function
Syntaxin binding
Resistance Mutations Across All Drugs
| Mutation | Drug | Source | Resistance Samples |
|---|---|---|---|
| p.T315I | Imatinib | COSMIC | 866 |
| p.I418V | Imatinib | COSMIC | 866 |
| p.E450A | Imatinib | COSMIC | 866 |
| p.E453L | Imatinib | COSMIC | 866 |
| p.E459K | Imatinib | COSMIC | 866 |
| p.M351T | Imatinib | COSMIC | 866 |
| p.F359I | Imatinib | COSMIC | 866 |
| p.E255K | Imatinib | COSMIC | 866 |
| p.E255V | Imatinib | COSMIC | 866 |
| p.L248V | Imatinib | COSMIC | 866 |
| p.A397P | Imatinib | COSMIC | 866 |
| p.M244V | Imatinib | COSMIC | 866 |
| p.E355G | Imatinib | COSMIC | 866 |
| p.Y253H | Imatinib | COSMIC | 866 |
| p.L364I | Imatinib | COSMIC | 866 |
| p.L267V | Imatinib | COSMIC | 866 |
| p.F359V | Imatinib | COSMIC | 866 |
| p.F317L | Imatinib | COSMIC | 866 |
| p.G250E | Imatinib | COSMIC | 866 |
| p.K294delinsRGG | Imatinib | COSMIC | 866 |
| p.K313delinsRGG | Imatinib | COSMIC | 866 |
| p.F311I | Imatinib | COSMIC | 866 |
| p.Q252H | Imatinib | COSMIC | 866 |
| p.V299L | Imatinib | COSMIC | 866 |
| p.E453G | Imatinib | COSMIC | 866 |
| p.Y253F | Imatinib | COSMIC | 866 |
| p.E275K | Imatinib | COSMIC | 866 |
| p.F378I | Imatinib | COSMIC | 866 |
| p.G269E | Imatinib | COSMIC | 866 |
| p.E274K | Imatinib | COSMIC | 866 |
| p.M263V | Imatinib | COSMIC | 866 |
| p.H396P | Imatinib | COSMIC | 866 |
| p.H415P | Imatinib | COSMIC | 866 |
| p.E274V | Imatinib | COSMIC | 866 |
| p.Y272H | Imatinib | COSMIC | 866 |
| p.T334I | Imatinib | COSMIC | 866 |
| p.F336L | Imatinib | COSMIC | 866 |
| p.M370T | Imatinib | COSMIC | 866 |
| p.H396R | Imatinib | COSMIC | 866 |
| p.Q252R | Imatinib | COSMIC | 866 |
| p.L387M | Imatinib | COSMIC | 866 |
| p.Q271H | Imatinib | COSMIC | 866 |
| p.Y272F | Imatinib | COSMIC | 866 |
| p.E374G | Imatinib | COSMIC | 866 |
| p.H415R | Imatinib | COSMIC | 866 |
| p.T315N | Imatinib | COSMIC | 866 |
| p.T334N | Imatinib | COSMIC | 866 |
| p.F378V | Imatinib | COSMIC | 866 |
| p.F359A | Imatinib | COSMIC | 866 |
| p.D276G | Imatinib | COSMIC | 866 |
| p.D295G | Imatinib | COSMIC | 866 |
| p.F486S | Imatinib | COSMIC | 866 |
| p.F505S | Imatinib | COSMIC | 866 |
| p.S417Y | Imatinib | COSMIC | 866 |
| p.S436Y | Imatinib | COSMIC | 866 |
| p.E478K | Imatinib | COSMIC | 866 |
| p.V299L | Bosutinib | COSMIC | 7 |
| p.L248R | Bosutinib | COSMIC | 7 |
| p.F359I | Bosutinib | COSMIC | 7 |
| p.L267R | Bosutinib | COSMIC | 7 |
| p.F378I | Bosutinib | COSMIC | 7 |
| p.T315V | Nilotinib | COSMIC | 3 |
| p.T334V | Nilotinib | COSMIC | 3 |