Porfimer sodium
DB00707
Approved Indication
Indicated in the treatment of esophageal cancer.
2
Targets
0
Resistance Mutations
0
References
3D Structure
No structure available
No co-crystal structure available
Protein Targets
Mechanism of Action
Cellular damage caused by porfimer is a consequence of the propagation of radical reactions. Radical initiation may occur after porfimer absorbs light to form a porphyrin excited state. Spin transfer from porfimer to molecular oxygen may then generate singlet oxygen. Subsequent radical reactions can form superoxide and hydroxyl radicals. Tumor death also occurs through ischemic necrosis secondary to vascular occlusion that appears to be partly mediated by thromboxane A2 release.
Details
DrugBank ID
DB00707 ↗
Approval Date
1995-12-27
Molecular Weight
— g/mol
Drug Class
Other
ATC Codes
L01XD01
Synonyms
Porfimer natrium, Porfimer sodico, Porfimère sodique