Teniposide
Topoisomerase Inhibitor
DB00444
Approved Indication
Teniposide is used for the treatment of refractory acute lymphoblastic leukaemia
1
Targets
0
Resistance Mutations
0
References
3D Structure
No structure available
No co-crystal structure available
Protein Targets
Mechanism of Action
The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA. Teniposide binds to and inhibits DNA topoisomerase II. The cytotoxic effects of teniposide are related to the relative number of double-stranded DNA breaks produced in cells, which are a reflection of the stabilization of a topoisomerase II-DNA intermediate.
Details
DrugBank ID
DB00444 ↗
Approval Date
2013-04-30
Molecular Weight
656.654 g/mol
Drug Class
Topoisomerase Inhibitor
ATC Codes
L01CB02
Synonyms
Epidophyllotoxin, Teniposid, Téniposide
PubChem
CID: 452548 ↗
ChEMBL
CHEMBL452231 ↗
SMILES
[H][C@]12COC(=O)[C@]1([H])[C@]([H])(C1=CC(OC)=C(O)C(OC)=C1)C1=CC3=C(OCO3)C=C1[C@@]2([H])O[C@]1([H])O[C@]2([H])CO[C@]([H])(O[C@@]2([H])[C@]([H])(O)[C@@]1([H])O)C1=CC=CS1
ADMET Profile
Computing properties…