Mitomycin
Alkylating Agent
DB00305
Approved Indication
For treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder. Also used as an adjunct to ab externo glaucoma surgery.
0
Targets
0
Resistance Mutations
0
References
3D Structure
No structure available
No co-crystal structure available
Protein Targets
Mechanism of Action
Mitomycin is activated in vivo to a bifunctional and trifunctional alkylating agent. Binding to DNA leads to cross-linking and inhibition of DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
Details
DrugBank ID
DB00305 ↗
Approval Date
2009-06-10
Molecular Weight
334.3272 g/mol
Drug Class
Alkylating Agent
ATC Codes
L01DC03
Synonyms
Ametycine, Mitamycin, Mitocin-C
PubChem
CID: 5746 ↗
ChEMBL
CHEMBL105 ↗
SMILES
CO[C@]12[C@H]3N[C@H]3CN1C1=C([C@H]2COC(N)=O)C(=O)C(N)=C(C)C1=O
ADMET Profile
Computing properties…