Masoprocol
DB00179
Approved Indication
Used for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated).
2
Targets
0
Resistance Mutations
0
References
3D Structure
No structure available
No co-crystal structure available
Protein Targets
Mechanism of Action
Although the exact mechanism of action is not known, studies have shown that masoprocol is a potent 5-lipoxygenase inhibitor and has antiproliferative activity against keratinocytes in tissue culture, but the relationship between this activity and its effectiveness in actinic keratoses is unknown. Masoprocol also inhibits prostaglandins but the significance of this action is not yet known.
Details
DrugBank ID
DB00179 ↗
Approval Date
—
Molecular Weight
302.3649 g/mol
Drug Class
Other
ATC Codes
L01XX10
Synonyms
Masoprocolum, meso-NDGA, Nordihydroguaiaretic acid
PubChem
CID: 71398 ↗
ChEMBL
CHEMBL313972 ↗
SMILES
C[C@@H](CC1=CC(O)=C(O)C=C1)[C@H](C)CC1=CC(O)=C(O)C=C1
ADMET Profile
Computing properties…