Pegaspargase
DB00059
Approved Indication
For treatment of acute lymphoblastic leukemia
0
Targets
0
Resistance Mutations
1
References
3D Structure
No structure available
No co-crystal structure available
Protein Targets
Mechanism of Action
Pegaspargase, more effective than asparaginase, converts asparagine to aspartic acid and ammonia. It facilitates production of oxaloacetate which is needed for general cellular metabolism. Some malignant cells lose the ability to produce asparagine and so the loss of exogenous sources of asparagine leads to cell death.
Details
DrugBank ID
DB00059 ↗
Approval Date
1994-02-01
Molecular Weight
— g/mol
Drug Class
Other
ATC Codes
L01XX24
Synonyms
Peg-asparaginase, Peg/L-asparaginase
ChEMBL
CHEMBL2108546 ↗
Drug References (DrugBank)