Asparaginase
DB00023
Approved Indication
For treatment of acute lympocytic leukemia and non-Hodgkins lymphoma
0
Targets
0
Resistance Mutations
1
References
3D Structure
No structure available
No co-crystal structure available
Protein Targets
Mechanism of Action
Asparaginase converts asparagine to aspartic acid and ammonia. It facilitates production of oxaloacetate which is needed for general cellular metabolism. Some malignant cells lose the ability to produce asparagine and so the loss of exogenous sources of asparagine leads to cell death.
Details
DrugBank ID
DB00023 ↗
Approval Date
—
Molecular Weight
— g/mol
Drug Class
Other
ATC Codes
L01XX02
Synonyms
Asparaginase (E. coli), L-asparaginase, L-asparagine amidohydrolase
ChEMBL
CHEMBL2108989 ↗
Drug References (DrugBank)