Sargramostim
DB00020
Approved Indication
For the treatment of cancer and bone marrow transplant
5
Targets
0
Resistance Mutations
0
References
3D Structure
No structure available
No co-crystal structure available
Protein Targets
Mechanism of Action
Sargramostim binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils
Details
DrugBank ID
DB00020 ↗
Approval Date
1991-05-01
Molecular Weight
— g/mol
Drug Class
Other
ATC Codes
L03AA09
Synonyms
GM-CSF
ChEMBL
CHEMBL1201670 ↗