Denileukin diftitox
DB00004
Approved Indication
For treatment of cutaneous T-cell lymphoma
3
Targets
0
Resistance Mutations
2
References
3D Structure
No structure available
No co-crystal structure available
Protein Targets
Mechanism of Action
Denileukin diftitox binds to the high-affinity IL-2 receptor complex. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes. The diphtheria toxin associated with Ontak then selectively kills the IL-2 bearing cells.
Details
DrugBank ID
DB00004 ↗
Approval Date
2008-10-15
Molecular Weight
— g/mol
Drug Class
Other
ATC Codes
L01XX29
Synonyms
Diphtheria toxin precursor, DT
ChEMBL
CHEMBL1201550 ↗
Drug References (DrugBank)